This analysis proposes radiomodulation of the nucleus accumbens as a promising intervention for alcohol use disorder, suggesting novel therapeutic avenues.
Despite progress in pharmaceutical and behavioral treatments, alcohol use disorder (AUD) continues to have a high relapse rate. While deep brain stimulation (DBS) of the nucleus accumbens (NAc) has shown therapeutic promise, its invasive nature poses significant risks. Radiomodulation, the focal delivery of sub-ablative ionizing radiation, offers a non-invasive alternative for neuromodulating deep brain structures. However, optimal targeting, dosing, and rationale for radiomodulation in AUD have not been discussed. This paper analyzes the NAc as a candidate target for radiomodulation and proposes NAc radiomodulation as a novel, potentially transformative therapeutic approach for AUD that warrants further investigation.
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Amurthur et al. (2025) studied this question.
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