Predict potential pharmacological mechanisms of Ling-gui-Zhu-gan Decoction in treating unstable angina pectoris using liquid chromatography-mass spectrometry and network pharmacology
This analysis reveals active compounds and targets in treating unstable angina using network pharmacology, suggesting novel therapeutic pathways.
Key Points
This study reveals that ling-gui-zhu-gan decoction can effectively influence unstable angina pectoris through multiple pathways.
The analysis identified three key active compounds—naringenin, glycyrrhizin, and calycosin—along with three core targets: TNF, EGFR, and PTGS2.
Using a combination of liquid chromatography-mass spectrometry and network pharmacology, researchers conducted a comprehensive chemical analysis of LGZGD.
These findings support the rational use and development of innovative formulations based on LGZGD for treating unstable angina pectoris.