Copper-catalyzed amidoalkylation of amines via C–C bond cleavage from cyclic oxaziridines

Xinxin Liu; Shaohong Wang; Yuan Zhang; Fan Yang; Hong-Jie Miao; Pengchen Ma; Lina Guo; Pin Gao

doi:10.1039/d5gc03001c

January 1, 2025Green Chemistry

Copper-catalyzed amidoalkylation of amines via C–C bond cleavage from cyclic oxaziridines

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Key Points

C–C bond cleavage enables a novel coupling reaction with amines, resulting in a highly efficient process.
The method achieves 100% atom-economy, which signifies minimal waste production during the reaction.
Copper acts as a catalyst under mild conditions, allowing for a redox neutral environment throughout the process.
This approach enhances efficiency in synthesizing amines, which are crucial in various chemical applications.

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Implication

The research demonstrates copper-catalyzed C–C bond cleavage in cyclic oxaziridines, highlighting 100% atom-economy in amine coupling.

Abstract

We have successfully established an efficient copper-catalyzed C–C bond cleavage of cyclic oxaziridines and the C(sp 3 )-N coupling reaction with amines under mild and redox neutral conditions with 100% atom-economy.

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5c54b1d3bfb60e55fd https://doi.org/10.1039/d5gc03001c

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Copper-catalyzed amidoalkylation of amines via C–C bond cleavage from cyclic oxaziridines

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Copper-catalyzed amidoalkylation of amines via C–C bond cleavage from cyclic oxaziridines

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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