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September 10, 2025International Journal of Neuroscience

Vagus Nerve Stimulation Ameliorates Learning-Memory Deficits and Suppresses Neuronal Apoptosis via the ERK/CREB/BDNF Signaling Pathway in Epileptic Rats

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Authors

YLYao LuShenyang University of TechnologyYLYang LiFujian Medical UniversityWSWenhao Su

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Implication

Vagus nerve stimulation enhances cognitive function and reduces neuronal apoptosis in epileptic rats, suggesting a role for the ERK/CREB/BDNF signaling pathway.

Key Points

  • Vagus nerve stimulation significantly improves cognitive function and reduces neuronal apoptosis in epileptic rats, supporting its potential therapeutic role.
  • The VNS treatment led to changes in neuronal morphology similar to those observed with sodium valproate therapy, indicating its efficacy.
  • ERK/CREB/BDNF signaling pathway activation was associated with reduced oxidative stress and neuroinflammation after VNS treatment.
  • Pathological changes linked to epilepsy were significantly ameliorated by VNS, highlighting its impact on neuronal health.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad6354b1d3bfb60e5a1fhttps://doi.org/10.1080/00207454.2025.2542882
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vagus Nerve Stimulation Therapy: Indications, Programing, and Outcomes2015 · 60 citations
  2. 2Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response2011 · 517 citations
  3. 3Vagus nerve stimulation: Surgical technique of implantation and revision and related morbidity2017 · 260 citations
  4. 4Excitatory Actions of GABA Increase BDNF Expression via a MAPK-CREB–Dependent Mechanism—A Positive Feedback Circuit in Developing Neurons2002 · 168 citations
  5. 5The Effect of Early Versus Late Onset of Major Motor Epilepsy upon Cognitive‐Intellectual Performance1975 · 149 citations