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The glucose sensor NSUN2-m5C modification regulates tumor-immune glucose metabolism reprogramming to drive hepatocellular carcinoma evolution

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Analysis uncovers the role of glucose metabolism in tumor evolution and immune responses in HCC, suggesting new therapies.

Glucose metabolism drives tumor evolution and enhances CD8+ T cell dysfunction, promoting hepatocellular carcinoma progression.
Key findings included the identification of NSUN2 as a regulator of GLUT1, stabilizing glucose uptake in tumor cells.
A murine tumor evolution model facilitated the identification of critical genes altering during tumor evolution across various samples.
The study suggests that targeting the GLUT1/NSUN2 axis, along with PD-L1 blockade, may reverse immunosuppression and combat tumor evolution.

He et al. (2025) studied this question.

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View Full Paper

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Authors

Analysis uncovers the role of glucose metabolism in tumor evolution and immune responses in HCC, suggesting new therapies.

Glucose metabolism drives tumor evolution and enhances CD8+ T cell dysfunction, promoting hepatocellular carcinoma progression.
Key findings included the identification of NSUN2 as a regulator of GLUT1, stabilizing glucose uptake in tumor cells.
A murine tumor evolution model facilitated the identification of critical genes altering during tumor evolution across various samples.
The study suggests that targeting the GLUT1/NSUN2 axis, along with PD-L1 blockade, may reverse immunosuppression and combat tumor evolution.

He et al. (2025) studied this question.

View Full Paper

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Bookmark