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September 10, 2025Journal of Applied Pharmaceutical ResearchOpen Access

Development and validation of stability indicating RP-HPLC method for nebivolol by using the DOE approach

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Authors

AGAnant GhongadeSBShruti Barot

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Overview

The method demonstrates high precision and sensitivity in quantifying nebivolol, indicating robust performance for stability assessments.

Key Points

  • The RP-HPLC method achieved a correlation coefficient of 1.00 across the concentration range of 80–120 µg/mL.
  • Forced degradation studies revealed that nebivolol is unstable under alkaline (15.94%) and oxidative (8.57%) conditions.
  • Limits of detection and quantification were determined at 0.55 µg/mL and 1.61 µg/mL, indicating high sensitivity.
  • This method shows promise for quality control and stability assessment of nebivolol formulations in pharmaceutical settings.

Cite This Study

Ghongade et al. (2025) studied this question.

synapsesocial.com/papers/68c1ae7054b1d3bfb60e66f1https://doi.org/10.69857/joapr.v13i3.1062
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