A photocatalytic approach produces 3-sulfonated vinylsilanes from α-bromoallylsilane, highlighting a versatile modification method in drug development.
A photocatalytic strategy for synthesizing 3-sulfonated vinylsilanes through photoinduced radical sulfur dioxide insertion into α-bromoallylsilane is presented. Using aryldiazonium or thianthrenium salts as aryl radical precursors, the reaction operates under mild conditions with various photocatalysts and SO2 sources. It exhibits a broad substrate scope, especially offering a practical approach for late-stage modification of drug molecules by providing valuable sulfone-containing vinylsilanes.
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Wang et al. (2025) studied this question.
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