Propensity score-matching analysis reveals no overall survival differences in adenocarcinoma patients, suggesting surgical approach may impact outcomes.
Background We aimed to investigate long-term survival outcome in patients with locally advanced esophagogastric junction adenocarcinoma and upper third gastric adenocarcinoma (EGJ-UG adenocarcinoma) who underwent proximal gastrectomy (PG) or total gastrectomy (TG). Methods We searched and analyzed the data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with T2–3 EGJ-UG adenocarcinoma receiving TG or PG were included. We performed a propensity score 1:2 matching, and matched datasets were generated and compared.We obtained the patients’ long-term survival benefits according to stratification of surgical approaches. Results Of 1,291 patients identified from the SEER database, 901 (69.8%) patients received PG and 390 (30.2%) patients received TG. After matching, 584 patients in the PG group were matched by propensity score to 344 patients in the TG group. There were no differences in overall survival and cancer-specific survival in matched data between different surgical approaches. For patients with tumor size ≤4 cm, similar long-term survival was observed in patients receiving PG and TG. For patients with tumor size >4 cm, TG was associated with improved overall survival and cancer-specific survival compared with PG. Conclusion This study has shown similar survival outcomes between PG and TG for patients with T2–3 EGJ-UG adenocarcinoma and with tumor size <4 cm.
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Liao et al. (2025) studied this question.
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