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September 10, 2025American Journal of Medical and Clinical Research & Reviews

Preimplantation Genetic Testing for Aneuploidy (PGT-A) on Blastocyst Quality, Vitrification Timing, and IVF Outcomes: A Comparative Study

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Authors

RRRoya RozatiMKMuhammad Siddique Ahmed KhanWTWajeeda Tabasum

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Overview

Comparative study reveals PGT-A improves blastocyst quality but not clinical outcomes in older patients.

Key Points

  • PGT-A enhances blastocyst quality, particularly inner cell mass and trophectoderm grading, but does not improve live-birth rates.
  • Patients in the PGT-A group had a mean age of 36.2 years, with significant rates of primary and female-factor infertility compared to controls.
  • Vitrification strategies varied, as PGT-A embryos were more likely to be frozen on Day 6, influencing embryo management practices.
  • Despite improvements in embryo quality indicators, the cumulative live-birth rate was lower in the PGT-A group at 75% versus 83.69% in controls.

Cite This Study

Rozati et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19954b1d3bfb60e915dhttps://doi.org/10.58372/2835-6276.1312
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The impact of PGT-A on in vitro fertilization outcomes in advanced-age women: a retrospective cohort study of 1808 Non-PGT-A cycles and 329 PGT-A cycles2026
  2. 2Feasibility of preimplantation genetic testing for aneuploidy on frozen-thawed embryos following conventional IVF insemination2024 · 1 citations
  3. 3Comparative clinical and reproductive outcomes following non-invasive versus biopsy-based preimplantation genetic testing for aneuploidy: a multicentric cohort study2026
  4. 4O-152 Pre-implantation genetic testing for aneuploidies (PGT-A) improves reproductive outcomes in advanced maternal age patients undergoing IVF/ICSI: a multicentre retrospective cohort study with propensity score matching2024 · 1 citations
  5. 5Outcomes of female reproductive performance with assisted reproductive techniques after recent mild to moderate COVID-19 infections: An observational study2024 · 2 citations