Scalable Biocatalytic Oxygenation of Aliphatic Amine Derivatives Using a Class I Unspecific Peroxygenase

Jiacheng Li; Katy A S Cornish; Jared Cartwright; William P. Unsworth; Gideon Grogan

doi:10.1039/d5cc03882k

January 1, 2025Chemical CommunicationsOpen Access

Scalable Biocatalytic Oxygenation of Aliphatic Amine Derivatives Using a Class I Unspecific Peroxygenase

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Key Points

The study demonstrates effective oxygenation of cycloalkylamines into cyclic amino ketones on a preparative scale.
Yielding amino alcohols highlights the versatility of the reaction while utilizing the class I unspecific peroxygenase enzyme.
The approach employs biocatalysis, which presents a sustainable method for chemical transformations in organic synthesis.
This work supports the potential for using biocatalysts in various industrial processes, expanding the scope of amine derivative applications.

Implication

Biocatalysis enhances regioselective oxygenation of cycloalkylamines into cyclic amino ketones, suggesting effective applications.

Abstract

artUPO is revealed as an effective biocatalyst for the regioselective oxygenation of cycloalkylamines to form cyclic amino ketones on preparative scale. Furthermore, amino alcohols can be formed via the selective...

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34654b1d3bfb60e979b https://doi.org/10.1039/d5cc03882k

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Scalable Biocatalytic Oxygenation of Aliphatic Amine Derivatives Using a Class I Unspecific Peroxygenase

Key Points

Implication

Abstract

Discussion

Cite This Study

Scalable Biocatalytic Oxygenation of Aliphatic Amine Derivatives Using a Class I Unspecific Peroxygenase

Key Points

Implication

Abstract

Discussion

Cite This Study

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