Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines

Amit Kumar; Kritika Dogra; Basab Bijayi Dhar

doi:10.1039/d5qo00961h

January 1, 2025Organic Chemistry FrontiersOpen Access

Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines

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Key Points

The synthesis of β-amino ketones is achieved effectively at 60 °C, demonstrating a novel copper-catalyzed method.
Employing hydrogen peroxide as an oxidant significantly enhances the reaction, leading to better yields of the desired products.
The use of 2-methyl-THF as a solvent offers an environmentally friendlier alternative compared to traditional solvents.
This innovative approach opens new pathways for synthesizing valuable intermediates in organic chemistry.

Implication

Copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines shows improved efficiency, suggesting a novel approach to organic synthesis.

Abstract

A copper-catalyzed method has been developed for synthesizing β-amino ketones using allyl alcohols and substituted anilines in 2-methyl-THF at 60 °C. This reaction employs hydrogen peroxide (H₂O₂) as the oxidant...

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Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34d54b1d3bfb60e99cb https://doi.org/10.1039/d5qo00961h

View Full Paper

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Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines

Key Points

Implication

Abstract

Discussion

Cite This Study

Oxidative copper-catalyzed synthesis of β-amino ketones from allyl alcohols and anilines

Key Points

Implication

Abstract

Discussion

Cite This Study

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