Role of gabaergic Drugs in the Treatment of Anxiety and Epilepsy

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Dysfunction of the GABAergic system has been implicated in various neurological and psychiatric disorders, particularly anxiety and epilepsy. GABAergic drugs, which modulate the GABA receptor activity, have become crucial therapeutic agents in managing these conditions. This review explores the mechanisms of action, clinical applications, and recent advancements in GABAergic drugs for the treatment of anxiety and epilepsy. Given the critical role of GABA in modulating neuronal excitability, the GABAergic system has been, and continues to be, an important target for efforts to identify new therapies for epilepsy, convulsive status epilepticus and other CNS disorders, including anxiety, sleep and depression.