Simple PTh‐MWCNT Nanocomposite Electrochemical Sensor for Detection and Quantification of Mitoxantrone

Mitoxantrone is a part of the anthracycline class of chemotherapy medicines. A primary concern of these anthracycline anticancer drugs is adverse cytotoxic effects, like myelosuppression, mucositis and possible cardiac toxicity. Designing a sensitive and quick technique for detecting and monitoring mitoxantrone in biological samples and pharmaceutical analysis is crucial. This study incorporated polythiophene polymer (PTh) with multi‐walled carbon nanotubes (MWCNTs) to form a nanocomposite using an in situ chemical oxidative polymerization method for electrocatalytic detection of mitoxantrone in human urine. The formation of the composite was confirmed using spectral, elemental and morphological analysis. Electrochemical techniques like cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were utilized to electrochemically characterize the composite modified electrode (PTh‐MWCNT/GCE) and carry out mitoxantrone detection. Analytical performance of PTh‐MWCNT/GCE in mitoxantrone was carried out for a linear range from 1 to 100 µM, showing a limit of detection of 8.92 nM. The modified electrode was also tested for reproducibility, stability, its performance in real samples (human urine) and recovery studies for mitoxantrone, with acceptable performance, making the PTh‐MWCNT composite a promising candidate for mitoxantrone detection.