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September 10, 2025Nepal Journal of BiotechnologyOpen Access

Potential Antimalarial Compounds from Spectroscopically Identified Compounds of Aqueous Stem-bark Extract of Magnifera indica: An In silico Approach

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Authors

ALAbdulhafiz LamiyaModibbo Adama University of TechnologySMS. B. MuhammadAhmadu Bello UniversityAAA. J. AlhassanBayero University Kano

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Overview

Spectroscopic techniques identify potential inhibitors of Plasmodium falciparum, suggesting new drug candidates.

Key Points

  • Oleic acid shows strong potential against plasmepsin II with a binding energy of -5.8 Kcal/mol.
  • Molecular docking analysis identified multiple phytochemicals as potential inhibitors for Plasmodium falciparum targets.
  • ADMET analysis indicates favorable pharmacokinetics and toxicity for most identified compounds.
  • Phthalic acid dibutyl ester presents slight nephrotoxicity, signaling the need for further validation before clinical use.

Cite This Study

Lamiya et al. (2025) studied this question.

synapsesocial.com/papers/68c1b60654b1d3bfb60eaff2https://doi.org/10.54796/njb.v13i1.383
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In-silico study of the bioactive compounds of Blighia sapida koenig revealed a novel Plasmodium falciparum Dihydroorotate dehydrogenase inhibitor for malaria2025
  2. 2An Integrated Network Pharmacology and Molecular Modelling Study of Phytoconstituents Targeting Malaria2025
  3. 3In silico Evaluation of the Antimalarial Potential of the Phytoconstituents of the Azadirachta indica Plant2022 · 4 citations
  4. 4In silico Evaluation of the Antimalarial Potential of the Phytoconstituents of the Azadirachta indica Plant2022
  5. 5In Silico Drug Discovery: Unveiling Potential Targets in Plasmodium falciparum through Molecular Docking Analysis2024