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September 10, 2025Acta BiomaterialiaOpen Access

Dynamic Release Kinetics and Biological Impact of Leachables from 3D-Printed Oral Devices: An Integrated In Vitro and Computational Exposure Model

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Authors

BABrigitte AltmannAHArmin HaukRTRainer Trittler

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Overview

This study demonstrates a dynamic exposure model assessing leachables in oral devices, indicating potential biological impacts.

Key Points

  • Dynamic in vivo monomer exposure peaks at specific time points, highlighting limitations of static models.
  • Analyzed urethane dimethacrylate release, showing inhibitory effects on metabolic activity in keratinocyte cultures.
  • The developed model integrates in vitro assessments and predicts biological effects, enhancing safety evaluations.
  • Findings suggest low-dose effects of leachables could have sensitizing impacts, even below cytotoxic levels.

Cite This Study

Altmann et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81254b1d3bfb60ebd78https://doi.org/10.1016/j.actbio.2025.08.003
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