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September 10, 2025AME Case ReportsOpen Access

A rare complication of thrombotic microangiopathy induced by chemotherapy for second breast cancer in a Hodgkin lymphoma survivor: a case report

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Authors

SWSong WangHLHuan LiuWWWei Wei

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Overview

Case report reveals challenges in diagnosing thrombotic microangiopathy in a breast cancer patient, highlighting potential interventions.

Key Points

  • Thrombotic microangiopathy was diagnosed after chemotherapy in a Hodgkin lymphoma survivor, leading to severe complications.
  • The patient, a 45-year-old female, presented multi-organ dysfunction with elevated lactate dehydrogenase and low haptoglobin.
  • Aggressive supportive measures were implemented, including plasma exchange, but the patient's condition worsened rapidly.
  • Findings suggest complement inhibition with eculizumab might benefit selected patients with chemotherapy-induced thrombotic microangiopathy.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81254b1d3bfb60ec0f2https://doi.org/10.21037/acr-24-247
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