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July 28, 2025Anatolian Current Medical Journal

Intraoperative perineural hyaluronic acid injection does not improve outcomes after carpal tunnel release in moderate-to-severe CTS: a retrospective cohort study

Mustafa Dinç Ömer Cevdet Soydemir Recep Karasu Bilal Aykaç Hünkar Çağdaş Bayrak

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Key Points

Intraoperative perineural hyaluronic acid injection did not improve outcomes after carpal tunnel release in moderate-to-severe CTS.
Both treatment groups saw improvements in pain and function, with VAS scores reducing from 7.0 to 2.0, showing benefits of carpal tunnel release.
This retrospective cohort study analyzed 130 patients receiving either carpal tunnel release alone or with hyaluronic acid injection.
Findings suggest that routine use of intraoperative hyaluronic acid is unnecessary, calling for further studies on earlier-stage disease.

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Implication

Retrospective cohort study shows no added benefits of hyaluronic acid in carpal tunnel release for CTS, indicating need for further research.

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Cite This Study

Dinç et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec3d3 https://doi.org/10.38053/acmj.1707263

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Comparative Effectiveness of Hyaluronidase Injections in Carpal Tunnel Syndrome: A Systematic Review and Meta-AnalysisMeta-Analysis · 2026
2Corticosteroid Injection Versus Surgical Decompression in Carpal Tunnel Syndrome: A Prospective Comparative Interventional Study Using Clinical, Electrophysiological, and Sonographic OutcomesCross-Sectional Study · 2026
3Ultrasound-guided Hydrogel Injection Provides Better Therapeutic Effects After Hand Tendon Surgery Than Intraoperative Injection: A Randomized Controlled Trial2024 · 4 citations
4Comparison of Ultrasound-guided Hydrodissection and Medical Therapy in Mild-to-Moderate Carpal Tunnel Syndrome: An Exploratory StudyCross-Sectional Study · 2026
5From mild to severe carpal tunnel syndrome: The role of ultrasound-guided perineural 5% dextrose injection: A prospective studyCohort Study · 2026 · 2 citations

More related papers

Comparative Study of Ultrasound-Guided Corticosteroid Injection with Acupotomy Release Versus Injection Alone in Carpal Tunnel Syndrome: A Randomized Controlled Trial2025
Ultrasound-Guided Perineural Corticosteroid Injection and Dextrose Hydrodissection for Carpal Tunnel Syndrome: Current Evidence and Clinical Considerations2026
Intraoperative Application of Hyaluronic Acid in Achilles Tendon Repair: A Retrospective Cohort Study on Short-Term Functional Outcomes2025

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