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September 10, 2025Journal of EthnopharmacologyOpen Access

Syringaresinol from Cinnamomum cassia (L.) J.Presl Ameliorates Cognitive Deficits and AD Pathology via AMPK in a DM-AD Mouse Model

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Authors

MMMajid ManzoorMIMuhammad Omer IqbalDWDan Wang

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Overview

Observational analysis shows enhanced cognitive function in a DM-AD mouse model through AMPK modulation, indicating potential therapeutic benefits.

Key Points

  • Syringaresinol significantly improved cognitive impairments and metabolic parameters in a DM-AD mouse model, demonstrating its neuroprotective properties.
  • Treatment with syringaresinol improved glucose tolerance and insulin sensitivity, with body weight gain reduction by up to a specific measure.
  • AMPK activation was crucial for syringaresinol's effects, validated through various biochemical assays and interactions with AMPK inhibitors.
  • The findings suggest that syringaresinol could serve as a natural therapeutic candidate for AD related to diabetes, emphasizing its potential role in treatment.

Cite This Study

Manzoor et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec3eahttps://doi.org/10.1016/j.jep.2025.120374
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