Dermatomyositis associated with gestational trophoblastic neoplasia: a case report

Introduction and Importance Dermatomyositis (DM) is an inflammatory myopathy with a known association with malignancies. The spectrum of associated cancers varies by age and geography, commonly including ovarian, lung, and breast cancers. However, its link with gestational trophoblastic neoplasia (GTN) has not been previously reported. Case Presentation A 45-year-old woman with recently treated GTN presented with proximal muscle weakness, a facial rash, and elevated muscle enzymes. She was diagnosed clinically with DM and responded well to corticosteroids and methotrexate. Clinical Discussion DM can occur before, during, or after cancer diagnosis. This rare case of DM following GTN supports the theory of immune cross-reactivity between tumor and muscle antigens. Diagnosis may rely on clinical criteria in resource-limited settings. Conclusion In patients with cancer who present with cutaneous manifestations and muscle symptoms, DM should be considered, irrespective of the cancer type or treatment status.