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September 10, 2025

Accelerating Cross-Modality Reaction Optimization via Robotically Automated Vacuum Enabled Direct-inject Mass Spectrometry (RAVE MS)

DHDaniel Holland-MoritzMerck & Co., Inc., Rahway, NJ, USA (United States)SMSarah R. MoorMerck & Co., Inc., Rahway, NJ, USA (United States)JPJoseph B. ParryMerck & Co., Inc., Rahway, NJ, USA (United States)

Puntos clave

This method enhances reaction optimization through advanced automation and mass spectrometry techniques.
Utilizing capillary electrophoresis hardware with a vacuum-enabled interface improves efficiency.
The system offers a streamlined process for sample injection, facilitating faster analysis.
Broad applicability in various chemical processes could lead to significant advancements in the field.

Resumen

In this report, we detail direct inject mass spectrometry via a Robotically Automated Vacuum Enabled (RAVE) interface that utilizes commercially available capillary electrophoresis hardware to directly inject samples for mass...

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Holland-Moritz et al. (Wed,) studied this question.

synapsesocial.com/papers/68c1b82654b1d3bfb60ec8e0 https://doi.org/https://doi.org/10.1039/d5re00248f

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