Leiomyoadenomatoid Tumour of the Uterus Presenting as Rare and Enigmatic Tumour: A Series of Three Cases

Leiomyoadenomatoid Tumour (LAT) of the uterus is an exceedingly rare neoplasm characterised by the intermingling of Adenomatoid Tumour (AT) components within a leiomyoma. A very small number of cases of LAT have been documented in the literature to date, and this case series presents three cases of LAT diagnosed at our institution. An ultrasonogram of all three cases showed large uteri with multiple intramural fibroids, except for one patient with subserosal fibroids, for whom surgery was performed. Histopathological examination of some of the nodules revealed smooth muscle bundles infiltrated by small tubular structures lined with cuboidal cells. Immunohistochemical tests confirmed the diagnosis of LAT, showing positivity for calretinin and negative results for Cluster of differentiation 34 (CD34) and Cytokeratins (CK7 and CK20). As the mainstay of treatment is surgery, all patients remained asymptomatic after hysterectomy. This series highlights the significance of identifying LAT as a distinct pathological entity to prevent misdiagnosis and ensure proper treatment.