Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Journal of Innovations in Cardiac Rhythm ManagementOpen Access

Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients with Atrial Fibrillation and Bioprosthetic Valve Replacement: An Umbrella Review

View Full Paper
Ask AI
Bookmark
Share

Authors

AKAlina Sami KhanALAbdullah LnuZAZain Ul Abideen

Discussion

Loading...

Member takes

Overview

Umbrella review shows direct oral anticoagulants reduce mortality and bleeding risks in patients with atrial fibrillation and bioprosthetic valve replacement, indicating better safety profiles.

Key Points

  • Direct oral anticoagulants lower all-cause mortality and bleeding risks compared to vitamin K antagonists in atrial fibrillation patients after valve surgery.
  • The pooled analysis demonstrated a risk ratio of 0.95 for all-cause mortality and 0.73 for major/life-threatening bleeding with direct oral anticoagulants.
  • The study utilized an umbrella review methodology that included 20 systematic reviews and meta-analyses of randomized controlled trials and observational studies.
  • Results suggest that direct oral anticoagulants may serve as more favorable alternatives to vitamin K antagonists, offering efficacy without the need for continuous monitoring.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb7054b1d3bfb60ed812https://doi.org/10.19102/icrm.2025.16075
View Full Paper
Ask AI
Bookmark
Share