Plasmonic Molecular Entrapment for Label‐Free Methylated DNA Detection and Machine‐Learning Assisted Quantification (Adv. Sci. 29/2025)

Advanced ScienceVolume 12, Issue 29 71025 FrontispieceOpen Access Plasmonic Molecular Entrapment for Label-Free Methylated DNA Detection and Machine-Learning Assisted Quantification (Adv. Sci. 29/2025) Muhammad Shalahuddin Al Ja'farawy, Muhammad Shalahuddin Al Ja'farawySearch for more papers by this authorVo Thi Nhat Linh, Vo Thi Nhat LinhSearch for more papers by this authorChaewon Mun, Chaewon MunSearch for more papers by this authorJun-Yeong Yang, Jun-Yeong YangSearch for more papers by this authorJun Young Kim, Jun Young KimSearch for more papers by this authorRowoon Park, Rowoon ParkSearch for more papers by this authorSung-Gyu Park, Sung-Gyu ParkSearch for more papers by this authorDong-Ho Kim, Dong-Ho KimSearch for more papers by this authorMin-Young Lee, Min-Young LeeSearch for more papers by this authorHo Sang Jung, Ho Sang JungSearch for more papers by this author Muhammad Shalahuddin Al Ja'farawy, Muhammad Shalahuddin Al Ja'farawySearch for more papers by this authorVo Thi Nhat Linh, Vo Thi Nhat LinhSearch for more papers by this authorChaewon Mun, Chaewon MunSearch for more papers by this authorJun-Yeong Yang, Jun-Yeong YangSearch for more papers by this authorJun Young Kim, Jun Young KimSearch for more papers by this authorRowoon Park, Rowoon ParkSearch for more papers by this authorSung-Gyu Park, Sung-Gyu ParkSearch for more papers by this authorDong-Ho Kim, Dong-Ho KimSearch for more papers by this authorMin-Young Lee, Min-Young LeeSearch for more papers by this authorHo Sang Jung, Ho Sang JungSearch for more papers by this author First published: 07 August 2025 https://doi.org/10.1002/advs.71025AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechatBluesky Graphical Abstract Label-Free Diagnosis The artwork highlights a breakthrough method for detecting and quantifying global DNA methylation. This highly sensitive approach leverages in situ surface growth of plasmonic particles to enable molecular trapping and label-free sensing. Combined with machine learning analysis, it allows precise quantification of global methylation levels, offering a promising strategy for early cancer diagnosis and comprehensive epigenetic profiling. More details can be found in article number 2503257 by Min-Young Lee, Ho Sang Jung, and co-workers Volume12, Issue29August 7, 202571025 RelatedInformation