Cryotherapy-induced hemorrhagic bullae: A case series

Cryotherapy is being used widely as a treatment option for various skin conditions due to its cost-effectiveness, convenience, and lack of invasiveness. As with any other procedure, cryotherapy has its share of complications. Among these, hemorrhagic bullae are not an uncommon complication. Hereby, we are reporting two cases with hemorrhagic bullae following cryotherapy. The first case was an 18-year-old male with multiple viral warts bilaterally over the limbs. But the patient developed bullae over all the treated sites around 24 h after cryotherapy. Similarly, another patient, a 55-year-old male, who was treated for multiple keloids present over the chest, abdomen, and left shoulder, also developed bullae over all the treated sites within the same time frame. Based on the findings of our report, it is essential to resolve the technical issues related to the delivery system and temperature monitoring during treatment administration. Before beginning cryotherapy, it is important to take into account not only the total number of lesions but also the total area they cover.