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September 10, 2025Journal of Chromatography BOpen Access

Development and validation of a ‘dilute and shoot’ LC–MS/MS method in urine suitable for screening and confirmation analyses in a clinical setting

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Authors

DFDimitra FlorouAOAmvrosios OrfanidisVBVassiliki A. Boumba

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Overview

This method detects 115 drugs in urine samples, highlighting its reliability and applicability in clinical settings.

Key Points

  • The LC-MS/MS method effectively quantifies 115 drugs and metabolites in urine samples, improving toxicological analysis.
  • Sensitivity metrics include LOD ranging from 0.01 to 1.5 ng/mL, demonstrating the method’s high detection capabilities.
  • Method validation included extensive testing for accuracy, precision, and selectivity, ensuring reliable results.
  • Findings indicate the method is suitable for both clinical and forensic applications, emphasizing its broad utility.

Cite This Study

Florou et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb7854b1d3bfb60edbc7https://doi.org/10.1016/j.jchromb.2025.124750
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