Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025

CMG2 interaction with actin is required for growth factor-induced chemotaxis in endothelial cells

View Full Paper
Ask AI
Bookmark
Share

Authors

FJFangfang JiangRMRaj Kumar MongreJTJacob Truman

Discussion

Loading...

Member takes

Overview

Affinity proteomics reveals CMG2 interaction with F-actin is critical for endothelial chemotaxis in response to growth factors.

Key Points

  • CMG2 interaction with actin is necessary for growth-factor-induced chemotaxis in endothelial cells.
  • Inhibition of chemotaxis using CMG2 antagonists results in the release of actin cytoskeleton from CMG2.
  • The study demonstrates that CMG2 co-localizes with actin at the cell leading edge, essential for directional movement.
  • The conserved actin binding domain of CMG2 directly associates with F-actin, suggesting its role in migration.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd2a54b1d3bfb60edfa3https://doi.org/10.1101/2025.07.21.665964
View Full Paper
Ask AI
Bookmark
Share