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Observational analysis shows inosine restores T cell function in newborns, suggesting improved immune defenses against respiratory viruses.
Early antibiotic exposure disrupts the gut microbiota, impairing newborn antiviral immunity. Stevens et al. uncover that inosine, a metabolite produced by gut bacteria, restores the function of antiviral T cells by modulating gene regulation, boosting lung immune defenses against respiratory viruses.
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Ziad Al Nabhani (2025) studied this question.
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