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September 10, 2025Journal of Translational MedicineOpen Access

Glucagon-like peptide-1 receptor agonists inhibit the progression of malignant pleural effusion in obese mice by regulating the metabolism of pleural effusion

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Authors

MSMingming ShaoState Grid Corporation of China (China)SDShu‐Feng DongCapital Medical UniversityQCQingyu ChenUnited States National Library of Medicine

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Implication

This investigation reveals how GLP-1 receptor agonists affect malignancy and metabolism in obese mice, suggesting potential therapeutic insights.

Key Points

  • GLP-1 receptor agonists significantly suppressed the progression of malignant pleural effusion in obese mice, extending survival time.
  • Injections of GLP-1 receptor agonists reduced blood glucose levels and altered the metabolomic profile of pleural effusion—enhancing nucleic acid metabolism and suppressing amino acid metabolism.
  • The methodology employed included a high-fat diet to induce obesity in mice and intrapleural injection of cancer cells for malignant pleural effusion modeling, followed by daily GLP-1RA administration.
  • These findings highlight the need for tailored treatment strategies for cancer patients with obesity or diabetes, as metabolic responses vary significantly between obese and normal-weight individuals.

Cite This Study

Shao et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3254b1d3bfb60ee54bhttps://doi.org/10.1186/s12967-025-06875-8
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