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September 10, 2025Oncology ReviewsOpen Access

Janus kinase inhibitors – a role for the treatment of cutaneous T-cell lymphomas?

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Authors

SPSharon PackerPBPatrick M. Brunner

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Overview

This review examines the potential of Jak inhibitors in treating cutaneous T-cell lymphoma, indicating an unmet need in therapy.

Key Points

  • Jak inhibitors may offer a new treatment avenue for patients with cutaneous T-cell lymphoma, addressing a significant unmet need.
  • Efficacy and safety of Jak inhibitors remain unclear and need validation through controlled clinical trials.
  • The review highlights evidence of Jak/stat pathway overactivation in mycosis fungoides, pointing to therapeutic targets.
  • Current treatment options are limited and often associated with complications, urging exploration of new therapies like Jak inhibitors.

Cite This Study

Packer et al. (2025) studied this question.

synapsesocial.com/papers/68c1c24454b1d3bfb60f0321https://doi.org/10.3389/or.2025.1482866
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