Photocatalytic Synthesis of 3,3-Disubstituted Cyclobutanols via Trifunctionalization of [1.1.1]Propellane

Jiacheng Li; Yue Wang; Yijun Jin; Longyi Li; Guoxiang Bao; Xingyi Zhu; Xinpeng Jiang

doi:10.1039/d5gc02651b

January 1, 2025Green Chemistry

Photocatalytic Synthesis of 3,3-Disubstituted Cyclobutanols via Trifunctionalization of [1.1.1]Propellane

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Key Points

Efficient trifunctionalization yields novel cyclobutanols, crucial for bioactive compounds and other applications.
Synthesis achieved using aqueous-phase methods, highlighting the utility of photocatalytic processes in organic chemistry.
The approach offers a valuable strategy in organic synthesis, addressing the scarcity of efficient cyclobutanol synthesis.
Potential implications include advanced development of pharmaceuticals and other bioactive materials through this method.

Implication

This research demonstrates photocatalytic trifunctionalization of [1.1.1]propellane, suggesting efficient synthesis of cyclobutanols.

Abstract

Cyclobutanols represent important structural motifs found in numerous bioactive compounds, however, efficient strategies for their synthesis remain scarce. Herein, we report an aqueous-phase trifunctionalization of [1.1.1]propellane via a synergistic approach...

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1c62654b1d3bfb60f1aab https://doi.org/10.1039/d5gc02651b

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Photocatalytic Synthesis of 3,3-Disubstituted Cyclobutanols via Trifunctionalization of [1.1.1]Propellane

Key Points

Implication

Abstract

Discussion

Cite This Study

Photocatalytic Synthesis of 3,3-Disubstituted Cyclobutanols via Trifunctionalization of [1.1.1]Propellane

Key Points

Implication

Abstract

Discussion

Cite This Study

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