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September 10, 2025American Journal of PediatricsOpen Access

Diagnosis and Management of Type 4-IV Osteogenesis Imperfecta from Intrauterine Life to School Age: A Clinical Case Study

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Authors

NJNour JelaliaAMAsma MarzoukRTRahma Thebti

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Overview

Clinical case illustrates the evolution of type IV osteogenesis imperfecta, highlighting complications in development stages.

Key Points

  • Diagnosis and management of type IV osteogenesis imperfecta begin in the prenatal phase, influencing childhood growth and development.
  • The study illustrates that mutations in COL1A1 and COL1A2 lead to varied phenotypes and complications throughout early life.
  • Clinical assessment provides insight into the impacts of OI on daily functioning and the quality of life for affected families.
  • Early identification and continued management of bone fragility can significantly affect long-term outcomes for affected individuals.

Cite This Study

Jelalia et al. (2025) studied this question.

synapsesocial.com/papers/68c1c63654b1d3bfb60f208bhttps://doi.org/10.11648/j.ajp.20251103.19
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Management of Endocrine Disease: Osteogenesis imperfecta: an update on clinical features and therapies2020 · 243 citations
  2. 2Diagnostic Challenges in Bone Fragility: Osteogenesis Imperfecta Case Series2025 · 3 citations
  3. 3Modern classification and molecular-genetic aspects of osteogenesis imperfecta2020 · 27 citations
  4. 4Osteogenesis imperfecta: Clinical diagnosis, nomenclature and severity assessment2014 · 816 citations
  5. 5Current Overview of Osteogenesis Imperfecta2021 · 97 citations