Nociplastic pain as a potential mechanism of pain?

<ns3:p>In 2016, the term “nociplastic pain” was introduced and officially recognized by the International Association for theStudy of Pain (IASP). This concept was proposed to address a diagnostic gap for certain pain syndromes, such asfibromyalgia, that did not align with the traditional classifications of nociceptive or neuropathic pain. Additionally,the term sought to describe pain that is not directly associated with tissue damage or nervous system pathology.Nociplastic pain refers to “altered nociception”, however, its introduction preceded a comprehensive understanding ofits biological foundations. In this article, the authors described the clinical potential of the new descriptor and criticallyappraised the justification for its implementation. The authors recommend caution while implementing the new termand emphasize the importance of further basic science research to better understand the biological determinants ofnociplastic pain.</ns3:p>