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September 10, 2025Nature CommunicationsOpen Access

Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis

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Observational analysis links glucocorticoid treatment with altered skeletal stem cell dynamics, suggesting potential therapies for bone loss.

GC treatment significantly reduces bone mass due to decreased bone formation by skeletal stem cells.
Increased numbers of endothelial cells display distorted features, contributing to vascular malformation.
Transplantation studies reveal direct crosstalk between skeletal stem cells and endothelial cells mediated by Basigin.
Anti-Basigin therapy significantly improves bone mass in 2-year-old mice following glucocorticoid administration.

Ambrosi et al. (2025) studied this question.

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Observational analysis links glucocorticoid treatment with altered skeletal stem cell dynamics, suggesting potential therapies for bone loss.