Novel α-tocopherol succinate-functionalized Pt(IV) complexes improve efficacy of cisplatin and oxaliplatin, suggesting potential benefits for cancer treatment.
Platinum(IV) prodrugs offer a promising strategy to overcome the limitations of cisplatin and oxaliplatin, including systemic toxicity and acquired resistance. In this study, two novel α-tocopherol succinate-functionalized Pt(IV) complexes, [Pt(oxalato)(DACH)(OAc)(α-TOS)]...
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Marotta et al. (2025) studied this question.
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