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September 10, 2025Journal of the American Chemical Society

Enantioselective Total Syntheses of Sannamycins A and B

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Authors

JZJingyang ZhangCentral South UniversityTSTsukasa ShimakawaUniversity of Illinois Urbana-ChampaignCUChad N. UngareanUniversity of Illinois Urbana-Champaign

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Implication

Research reports enantioselective syntheses of sannamycins A and B from benzene, indicating new pathways to aminoglycoside antibiotics.

Key Points

  • The study achieved enantioselective syntheses of sannamycins A and B, showcasing innovative methods in antibiotic design.
  • Syntheses involved a novel dearomative hydroamination and stereoselective glycosylation, highlighting advancements in synthesis techniques.
  • The process utilized Cyrene for carbohydrate elaboration, leading to the natural products in 14 and 17 steps respectively.
  • This work supports the potential for more accessible syntheses of aminoglycoside antibiotics, addressing longstanding challenges in the field.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c1cc3754b1d3bfb60f45c3https://doi.org/10.1021/jacs.5c11901
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