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Redefining Lung Cancer Therapy — A Long-Awaited Shift in Strategy

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Neoadjuvant immune-checkpoint inhibitor therapy shows promise in improving treatment outcomes for lung cancer.
The CheckMate 816 trial compares major pathological response rates between nivolumab plus ipilimumab and traditional chemotherapy.
Surgery has been the main treatment for early-stage non–small-cell lung cancer, but recurrence remains a challenge.
The findings imply a shift in the standard approach to treating non–small-cell lung cancer with combination therapies.

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Phase 3 CheckMate 816 trial evaluates neoadjuvant immune-checkpoint therapy in NSCLC patients, suggesting a strategic shift in treatment.

Virginia Calvo (2025) studied this question.

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