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September 10, 2025HematologyOpen Access

Role of eIF4E in mediating cytotoxic effect of HHT and ATO on AML cells in bone marrow microenvironment

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Authors

PCPing ChenXLXiaojing LiWZWeiwu Zhan

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Overview

Analysis shows eIF4E modulates cytotoxicity in AML, suggesting microenvironment-targeted therapies.

Key Points

  • eIF4E modulation significantly impacts the cytotoxicity of HHT and ATO on acute myeloid leukemia cells.
  • Elevated eIF4E expression correlates with poorer prognosis, indicating its potential as a therapeutic target.
  • The stromal-AML co-culture system was utilized to examine the protective mechanism of the bone marrow microenvironment.
  • Genetic studies demonstrated that eIF4E knockdown enhances sensitivity to chemotherapy, while overexpression leads to resistance.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1d01a54b1d3bfb60f611ehttps://doi.org/10.1080/16078454.2025.2546734
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