This investigation analyzes conformational changes in bispidines, indicating how substituents affect rotational motion.
A detailed conformational analysis of N-substituted bispidines has been performed to determine the factors governing the restricted rotational motion induced by the substituents. This investigation combines computational studies of the transition state involved in the rotation with experimental characterization of the rotamers arising from the restricted rotation.
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Migliano et al. (2025) studied this question.
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