This method demonstrates high yields and diastereoselectivities in α-aminophosphonates from N,O-acetals, suggesting significant advancements in phosphonylation techniques.
An efficient approach to α-aminophosphonates has been developed through an Fe(OTf)3-catalyzed N-α phosphonylation of N,O-acetals with triethyl phosphite. As a result, a series of 2,6-cis and 2,5-trans α-aminophosphonates were obtained in moderate to excellent yields and with excellent diastereoselectivities (dr up to 19:1).
No takes yet. Share an insight, caveat, or question.
Sun et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: