Feasibility and Preliminary Efficacy of Digital Cognitive Training in Parkinson’s Disease with Mild Cognitive Impairment: A Pilot Study

Cognitive impairment is common in Parkinson's disease (PD), with few pharmacological options. We evaluated the effects of a digital cognitive training program (SUPERBRAIN), previously effective in Alzheimer's risk populations, on cognitive function in PD. Twenty-nine patients with PD and mild cognitive impairment (PD-MCI) from four clinics were randomized to intervention (n=16) or control (n=7). The intervention group completed a 12-week, home-based, tablet cognitive training program (25-30 min/day, 7 days/week). Cognitive outcomes were assessed using the Seoul Neuropsychological Screening Battery pre- and post-intervention. Adherence was 79.4%. The intervention group showed significant improvements in the Seoul Verbal Learning Test (SVLT) delayed recall and controlled oral word association test, with no changes in controls. ANCOVA confirmed a greater SVLT improvement in the intervention group ((F-statistics = 7.15, P-value = 0.015, partial η² = 0.28). SUPERBRAIN is feasible and improves cognitive function in PD-MCI.