Molecular dynamics simulation of a nanofluidic memristor based on deoxyribonucleic acid origami deformation emulates synaptic functions

Ion-based memristors constructed within a fluidic environment have emerged as promising platforms for simulating neuronal activities and advancing neuromorphic computing. In this study, we design a deoxyribonucleic acid (DNA) origami-silicon nitride (SiN) hybrid nanofluidic memristor based on the molecular dynamics (MD) simulation. The memristive properties of the nanofluidic device stem from the dynamic deformation of the DNA origami plate, which modulates ionic conductance by partially obstructing the SiN nanopore. Pulse response tests validate the ability of nanofluidic memristors to emulate key synaptic plasticity behaviors. Furthermore, we introduce Mg2+ ions as a chemical stimulus, which can enhance the structural stability of the DNA origami plate through interactions with the phosphate groups. By tuning the polarity of the applied pulse voltage, the nanofluidic memristor can mimic responses to both excitatory and inhibitory chemical stimuli. These advancements demonstrate the versatility and potential of DNA origami-SiN hybrid nanofluidic memristors in neuromorphic computing applications.