Estimating changes in RNA Polymerase II elongation and intron splicing speeds from total RNA-seq data

Jakub Koubele; Andreas Beyer

doi:10.1101/2025.08.24.672013

August 28, 2025Open Access

Estimating changes in RNA Polymerase II elongation and intron splicing speeds from total RNA-seq data

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Key Points

The findings indicate a method to assess changes in rna polymerase ii elongation speed and intron splicing speed.
This research reveals that utilizing total rna-seq can efficiently provide insights into gene expression mechanisms.
A new computational method has been developed for simultaneous estimation of elongation and splicing speeds using existing RNA sequencing data.
Understanding these speeds offers opportunities to further investigate their roles in gene expression regulation.

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Implication

Computational method estimates RNA Polymerase II elongation and splicing speeds from total RNA-seq data, indicating potential impacts on gene expression.

Abstract

We present a computational method to jointly estimate changes in the elongation speed of RNA Polymerase II, and the speed of intron splicing, using total RNA-seq. An implementation of our method is available at https://github.com/jkoubele/pol-ii-speed.

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Koubele et al. (2025) studied this question.

synapsesocial.com/papers/68c1d98554b1d3bfb60fb444 https://doi.org/10.1101/2025.08.24.672013

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Estimating changes in RNA Polymerase II elongation and intron splicing speeds from total RNA-seq data

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Estimating changes in RNA Polymerase II elongation and intron splicing speeds from total RNA-seq data

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Abstract

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