Analysis quantifies anisotropic behavior in electron density surfaces, highlighting σ-holes in atomic properties.
Some atomic properties such as an atomic charge are isotropic, but every now and then some derivations of them become anisotropic, for example the plotting of the Molecular Electrostatic Potential (MEP) on the electron density surface can exhibit some anisotropic behavior; quantifying it can be a bit challenging.
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Joaquin Barroso (2016) studied this question.
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