Background: The present study was done to evaluate the diagnostic performance of mp MRI in suspected in Prostate Cancer Patients at tertiary care Hospital. Materials and Methods: Forty-four patients with suspected PCa on clinical assessment and/or raised serum PSA levels (>4ng/ml) were prospectively recruited. Patient who underwent prostatic biopsy prior to 68Ga-PSMA PET/CT and mp MRI, deranged renal function tests or coagulogram and refused consent were excluded. Out of total 44, 33 patients also underwent mp MRI. Out of the total 44 patients, 33 underwent biopsy. Only 22 out of these 33 patients underwent mp MRI. The images were interpreted and mp MRI reporting was done according to PIRADS v.2. Histopathology was taken as gold standard. Results: Mean age of patients was 66.61±9.3 years and Malignancy was detected in 16/33 (48.5%) patients who underwent biopsy. Out of these 22 patients, 9 were interpreted as PIRADS II, 3 patients were PIRADS III and 10 were given PIRADS score of IV/V. No patient was given a PIRADS score of 1. When PIRADS III-V were considered as positive lesions on mp MRI, the sensitivity, specificity, PPV, NPV and accuracy of mp MRI was 100%, 81.82%, 84.62%, 100% and 90.91% respectively to detect the adenocarcinoma PCa. When PIRADS III was considered as negative for malignancy, the sensitivity falls to 81.82%, specificity increases to 90.91%, PPV increased to 90%, NPV decreased to 83.33% and he overall accuracy decreased from 90.91 to 86.36%. Conclusions: Present study concluded that the Majority of the patients with PIRADS IV/V had a diagnosis of malignancy and mp MRI has high sensitivity, specificity, PPV, NPV and accuracy in diagnosis of Prostate Cancer.
Sharma et al. (Fri,) studied this question.