Analysis of tetrasaccharide resin glycosides shows nitric oxide production inhibition in RAW 264.7 cells, suggesting potential therapeutic applications.
LC-HRMS/MS-based molecular-network-guided chemical investigation of Cuscuta campestris led to the isolation of seven undescribed tetrasaccharide-type resin glycosides (1-7). Their structures were elucidated using 1D and 2D NMR and HRESIMS analysis. Isolated resin glycosides were comprised of d-glucose, d-fucose, d-quinovose, and l-rhamnose, and these monosaccharides were partially acylated with acetyl, isobutyryl, n-hexanoyl, and niloyl organic acids. The absolute configuration of aglycones were determined as S-configuration using Mosher's method after acid hydrolysis of resin glycoside fraction. All compounds were evaluated for their inhibitory activity against the production of nitric oxide in RAW 264.7 cells. Compounds 2 and 3 exhibited inhibitory activity, with IC50 values of 14.3 and 10.4 μM, respectively.
No takes yet. Share an insight, caveat, or question.
Han et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: