infection in patients with colorectal adenocarcinoma and its association with tumor grade and location: a cross-sectional study.

Given the positive results of some research, this study aimed to explore the relationship between the presence of Helicobacter pylori (HP) in gastric histopathology and the location and grade of tumors in an institutional sample of patients diagnosed with colorectal cancer (CRC). Epidemiological studies have been conducted to investigate the association between HP infection and CRC. This cross-sectional study retrieved data from the hospital database, considering inclusion criteria and medical record availability for patients who underwent both endoscopy and colonoscopy and were diagnosed with CRC. Patients were grouped based on tumor grade and location and compared regarding the presence or absence of HP pathogen in endoscopic biopsy direct smears. Data from 241 patients were available, 220 of whom had adenocarcinoma. A statistically significant relationship between tumor differentiation grade and HP positivity was observed (P= 0.001). Each 1-level increase in grade was associated with 2.2 times higher odds of HP positivity. No significant relationships existed in the analysis of tumor location related to HP positivity. In colorectal cancer patients, the presence of the HP pathogen may be linked to a higher likelihood of high-grade colorectal cancers. This finding needs to be explored in screening cohorts.