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September 14, 20254 citations

NIR-II Imaging and Nanomotors for Enhanced Thrombolysis in Pulmonary Embolism

NIR-II Imaging-Guided Self-Penetrating Nanomotors for Millimeter-Scale Deep Thrombolysis Tracking and Accelerated Embolus Clearance.

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Authors

MLMeng Li LiuRZRongyuan ZhangBCBinbin Chen

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Overview

Self-propelling nanomotors improve thrombolysis and monitoring in pulmonary embolism, suggesting effective theranostics strategies.

Key Points

  • The self-penetrating nanomotors achieved over 95% embolus clearance in pulmonary embolism cases, indicating significant therapeutic potential.
  • Using only 13.6% of the typical urokinase dose, the therapy accelerated embolus clearance while maintaining patient safety.
  • Integration of NIR-II imaging and thrombus-targeting facilitates enhanced detection and monitoring of thrombolytic progress.
  • Validation in both the posterior auricular artery thrombosis and microemboli models highlights the versatility and effectiveness of the system.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c6df6933b72be0b5e43ddbhttps://doi.org/10.1002/adma.202512075
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