Observational analysis shows diffuse gastric uptake on PET/CT in a patient with systemic mastocytosis, indicating possible myeloma involvement.
A 65-year-old man with systemic mastocytosis and associated hematological neoplasm (plasma cell myeloma, SM-AHN) received an 18F-FDG PET/CT for staging. In addition to the typical bone marrow and splenic uptake, PET/CT also showed diffuse 18F-FDG uptake in the gastric wall. It suggested the involvement of myeloma or mastocytosis. Subsequent histopathologic analysis of gastric biopsy specimens through endoscopy confirmed the diagnosis of mastocytosis involvement.
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Zhao et al. (2025) studied this question.
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