September 16, 2025

Urolithin a modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing.

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Authors

ARAntonis RoussosNational and Kapodistrian University of Athens KKKaterina KitopoulouNational and Kapodistrian University of Athens FBFivos BorbolisUniversity of Patras

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Implication

Observational analysis shows urolithin A improves inter-organellar communication in aging cells, highlighting its potential for healthspan enhancement.

Key Points

Urolithin A significantly improves organellar communication and promotes healthy aging, boosting lifespan and muscle function.
Key evidence reveals that urolithin A-induced mitophagy enhances calcium signaling, crucial for mitochondrial and lysosomal interactions.
Multi-omic analysis demonstrated that urolithin A reorganizes mitochondria, lysosomes, and the endoplasmic reticulum for improved cellular health.
Results imply that urolithin A may serve as a therapeutic target for age-related mitochondrial dysfunction and diseases.

Cite This Study

Roussos et al. (2025) studied this question.

synapsesocial.com/papers/68c93fee01120bef803bb16d https://doi.org/10.1080/15548627.2025.2561073

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Implication

Observational analysis shows urolithin A improves inter-organellar communication in aging cells, highlighting its potential for healthspan enhancement.

Urolithin a modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing.

Discussion

Member takes

Implication

Key Points

Cite This Study

Urolithin a modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing.

Discussion

Member takes

Implication

Key Points

Cite This Study

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