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September 16, 2025

Abatacept Improves Post-Transplant Survival and Reduces Endothelial Injury Syndromes in Beta-Thalassemia major.

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Authors

PKPooja KhandelwalCincinnati Children's Hospital Medical CenterAIAzada IbrahimovaCincinnati Children's Hospital Medical CenterALAdam LaneCincinnati Children's Hospital Medical Center

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Implication

Retrospective review shows abatacept reduces graft versus host disease in children with beta thalassemia, suggesting improved outcomes.

Key Points

  • Abatacept lowered the incidence of endothelial injury syndromes to 16% from 64% without it, enhancing post-transplant survival.
  • Acute grade II-IV graft versus host disease was eliminated in the abatacept group (0%), a significant difference compared to 35% in controls.
  • This retrospective review analyzed children with beta thalassemia major who underwent hematopoietic stem cell transplant.
  • Using abatacept improved thalassemia-free survival rates to 100%, indicating potential for better transplant outcomes.

Cite This Study

Khandelwal et al. (2025) studied this question.

synapsesocial.com/papers/68c93fee01120bef803bb180https://doi.org/10.1182/bloodadvances.2025017197
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